H2N2V1, Main, Exploration, bibRecord, 002877

Influenza virus: appearance of high mouse-neurovirulent recombinants.

Identifieur interne : 002877 ( Main/Exploration ); précédent : 002876; suivant : 002878

Influenza virus: appearance of high mouse-neurovirulent recombinants.

Auteurs : A. Vallbracht ; B. Flehmig ; H J Gerth

Source :

Intervirology [ 0300-5526 ] ; 1979.

RBID : pubmed:429139

Descripteurs français

KwdFr :
- Animaux, Encéphale (microbiologie), Recombinaison génétique, Réplication virale, Souris, Virulence, Virus de la grippe A (croissance et développement), Virus de la grippe A (génétique), Virus de la grippe A (pathogénicité).
MESH :
- croissance et développement : Virus de la grippe A.
- génétique : Virus de la grippe A.
- microbiologie : Encéphale.
- pathogénicité : Virus de la grippe A.
- Animaux, Recombinaison génétique, Réplication virale, Souris, Virulence.

English descriptors

KwdEn :
- Animals, Brain (microbiology), Influenza A virus (genetics), Influenza A virus (growth & development), Influenza A virus (pathogenicity), Mice, Recombination, Genetic, Virulence, Virus Replication.
MESH :
- genetics : Influenza A virus.
- growth & development : Influenza A virus.
- microbiology : Brain.
- pathogenicity : Influenza A virus.
- Animals, Mice, Recombination, Genetic, Virulence, Virus Replication.

Abstract

Recombinants from two influenza A strains that lacked mouse neurovirulence were tested, along with their parent strains, for mouse neurovirulence and for the ability to propagate in dissociated mouse embryo brain cells. The parents used were (i) strain A/Rostock/34 (FPV) (Hav1N1), with a high chicken neurovirulence, and (ii) the mouse-lung-adapted human strain Engl/1/61 (H2N2), lacking neurovirulence. In some of the recombinants high mouse neurovirulence could be detected after intracerebral inoculation of low virus doses. There was neither a correlation between surface antigen and neurovirulence nor between neurovirulence and mouse lung virulence in our system, although neurovirulence was only found in strains with Hav1 hemagglutinin. There was an association between replication in mouse embryo brain cells in culture and high mouse neurovirulence.

DOI: 10.1159/000149007
PubMed: 429139

Affiliations:

Le document en format XML

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<author><name sortKey="Flehmig, B" sort="Flehmig, B" uniqKey="Flehmig B" first="B" last="Flehmig">B. Flehmig</name>
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<author><name sortKey="Gerth, H J" sort="Gerth, H J" uniqKey="Gerth H" first="H J" last="Gerth">H J Gerth</name>
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<term>Influenza A virus (pathogenicity)</term>
<term>Mice</term>
<term>Recombination, Genetic</term>
<term>Virulence</term>
<term>Virus Replication</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Encéphale (microbiologie)</term>
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<term>Virulence</term>
<term>Virus de la grippe A (croissance et développement)</term>
<term>Virus de la grippe A (génétique)</term>
<term>Virus de la grippe A (pathogénicité)</term>
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<term>Mice</term>
<term>Recombination, Genetic</term>
<term>Virulence</term>
<term>Virus Replication</term>
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<front><div type="abstract" xml:lang="en">Recombinants from two influenza A strains that lacked mouse neurovirulence were tested, along with their parent strains, for mouse neurovirulence and for the ability to propagate in dissociated mouse embryo brain cells. The parents used were (i) strain A/Rostock/34 (FPV) (Hav1N1), with a high chicken neurovirulence, and (ii) the mouse-lung-adapted human strain Engl/1/61 (H2N2), lacking neurovirulence. In some of the recombinants high mouse neurovirulence could be detected after intracerebral inoculation of low virus doses. There was neither a correlation between surface antigen and neurovirulence nor between neurovirulence and mouse lung virulence in our system, although neurovirulence was only found in strains with Hav1 hemagglutinin. There was an association between replication in mouse embryo brain cells in culture and high mouse neurovirulence.</div>
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Influenza virus: appearance of high mouse-neurovirulent recombinants.

Influenza virus: appearance of high mouse-neurovirulent recombinants.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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